In Indian traditional system of medicine, the plant of Madhuca indica J.F. Gmel. (Sapotaceae) is recommended for the management of peptic ulcer. In light of this, the present investigation was carried out to study the antiulcer activity of various doses (100, 200 and 400 mg/kg, p.o) of petroleum ether (MI-PEE) and aqueous extract (MI-AQE) of Madhuca indica J.F. Gmel, employing the ethanol and pylorus ligation induced gastric ulcer models in rats. In ethanol induced ulcer model, MI-AQE extract provided significant ulcer protective effect and increseased in mucin content at the dose of 200 and 400 mg/kg, (P < 0.001). And also, in pylorus ligation model, ulcerated area was found to reduce significantly MI-AQE, at the dose of 200 and 400 mg/kg (P < 0.001) through increseased in gastric pH and mucin content at the dose of 200 and 400 mg/kg (P < 0.001) along with reduction in total acidity and pepsin content at the dose of 100 mg/kg, (P < 0.01), 200 and 400 mg/kg, (P < 0.001). It is concluded that MI-AQE but not MI-PEE showed antiulcer activity.
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